| Interaction | Explanation |
|---|---|
| associated | The general relation associated describes that two concepts are mentioned within the same sentence and connected via a verb/keyword. |
| administered | Administered describes that some substance (Chemical, Drug, Excipient or Plant Family) is given in a dosage dorm (tablet, injection, etc.). |
| compares | Compares describes that some concepts are compared. |
| decreases | Decreases describes that some effect is lowered, e.g., a drug might lower the expression of some target. A search for decreases also includes searches for the inhibits relation. |
| induces | Induces describes that some effect / expression is increased, e.g., a drug might increase the expression of a disease. Induces may be used to search for side effects. |
| interacts | Interacts describe an interaction between concepts (drugs, targets, etc.). A search for interacts also includes searches for metabolises and inhibits. |
| inhibits | Inhibits describes an inhibition of some target, e.g., a drug might inhibit some target. |
| metabolises | Metabolises describes that a target is metabolised by some substance, e.g., a drug might be metabolised by a target. |
| method | Method describes a relation that involves a method or lab method, e.g., a drug might be analysed via a method. |
| treats | Treats describe that some disease or species is treated with a substance (Chemical, Drug, Excipient), e.g., a drug might prevent or lower the expression of some disease. |
The following table displays which regular expressions and synonyms we consider to represent an interaction. We also provide this list as a JSON file.
| Interaction | Explanation |
|---|---|
| associated | General relation. Any predicate and those special words: associat*, contain, produce, convert, yield, isolate, generate, synthesize, grow, occures, evaluat*, augment, effect, develop*, affect, contribut*, involve, isa, same as, coexists with, process, part of, associate, play, limit, show, present, exhibit, find, form |
| administered | Relation between Dosage Forms and any other concept. receiv*, administrat* |
| compares | compar*, correlate*, correspond* |
| decreases | reduc*, lower*, attenuat*, mediate, downregulat*, down-regulat*, down regulat* |
| induces | stimulat*, increas*, potentiat*, enhanc*, activat*, lead, cause, side effect*, adverse, complication*, drug toxicit*, drug injur*, upregulat*, up regulat*, up-regulat* |
| interacts | bind, interact*, target*, regulat*, block* |
| inhibits | disrupt*, suppres*, inhibit*, disturb* |
| metabolises | metabol* |
| method | Relation between Methods and any other concept. method* |
| treats | prevent*, use, improv*, promot*, sensiti*, aid, treat*, *therap* |
The following hierarchy displays how interactions are expanded in our system, e.g., associated is expanded to any other relation or interacts is expanded to interacts.